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Rheumatoid-like Arthritis Preceding Brain Tumor

Joseph W. Leonard, MD
Arch Intern Med. 1981;141(1):139. doi:10.1001/archinte.1981.00340010131030.
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To the Editor.  —Simon and Ford, in the May Archives (1980;140:698-700), recorded a case of rheumatoid-like arthritis associated with colonic carcinoma. I would like to report an association of polyarthritis that preceded the appearance of a brain tumor.

Report of a Case.  —A 37-year-old man was first seen Nov 6, 1974, with a three-month history of arthritis. He had noted stiffness, swelling, and pain in various joints including the knees, the wrists, the hands, and the right ankle. Findings included symmetrical swelling of the knees, right ankle, wrists, and tenderness of the metacarpal phalangeal joints of the hands. Left knee effusion was present. Laboratory investigation included an elevated ESR, a normal uric acid level, a negative test result for rheumatoid factor, and no lupus erythematosus cells. Treatment included anti-inflammatory agents, aspirin, and prednisone. Follow-up during the next five months showed the symptoms and signs of polyarthritis to be subsiding. The


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