We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Bullous Pemphigoid as a Manifestation of Chronic Lymphocytic Leukemia

Lawrence Tim Goodnough, MD; W. Angus Muir, MD, PhD
Arch Intern Med. 1980;140(11):1526-1527. doi:10.1001/archinte.1980.00330220077028.
Text Size: A A A
Published online

• We describe a patient with chronic lymphocytic leukemia (CLL) and bullous pemphigoid. Initial treatment with high-dose prednisone (60 mg/day for 14 days) failed to prevent occurrence of new skin lesions. After the addition of chlorambucil, 6 mg/day, and tapering the prednisone dosage, no new skin lesions appeared, and the bullous lesions rapidly resolved. We were unable to isolate an antibody produced by leukemic lymphocytes that is directed against subepithelial basement membrane. Nevertheless, we believe that bullous pemphigoid can be a peripheral manifestation of an underlying disease such as CLL. Confirmation of this would be aided by the isolation of antibody produced by leukemic cells that is directed against subepithelial basement membrane.

(Arch Intern Med 140:1526-1527, 1980)


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.