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Graves' Disease and Idiopathic Thrombocytopenic Purpura

D. Huhn, MD; E. Hiller, MD
Arch Intern Med. 1980;140(9):1252-1253. doi:10.1001/archinte.1980.00330200128047.
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To the Editor.  —The association between hyperthyroidism and idiopathic thrombocytopenic purpura (ITP) is a known condition that has been published in several case reports1-3 and may be due to the existence of a common autoimmune mechanism. In addition, the refractiveness of treatment of ITP in the face of a coexisting thyrotoxicosis was observed1-3 and complemented by a case report by Resnitzky et al, in the Archives (139:483-484, 1979). As this subject may be of great clinical importance and must still be considered controversial,4 a further report of such a case is presented.

Report of a Case.  —In a 23-year-old woman, the diagnosis of ITP was confirmed in June 1978. The platelet count rose to 80,000/μL when 150 mg of prednisolone (2 mg/kg) per day was given, but dropped to values of less than 20,000/μL when the prednisolone dosage was gradually reduced to 15 mg/day. In October 1978,


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