We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Mental Confusion Falsely Attributed to Cimetidine

Bernard Leo Remakus, BS, MEd, MD; Theodore M. Onifer, MD
Arch Intern Med. 1980;140(9):1251. doi:10.1001/archinte.1980.00330200127042.
Text Size: A A A
Published online


To the Editor.  —Multiple reports have appeared in the literature during the past three years suggesting a direct relationship between cimetidine and mental confusion in selected individuals.1,2 In a number of these reports, allusion has been made to the presence of concomitant factors that might have contributed to the observed alterations in mental status.3-6 To illustrate the potential danger in causality assessment, we wish to report the following case.

Report of a Case.  —A 74-year-old man was hospitalized with upper gastrointestinal tract hemorrhages on two separate occasions within a nine-month period. During his first hospitalization, he was treated with cimetidine, and acute changes in mental status developed that were thought to be directly related to the drug. These changes included confusion, agitation, and auditory and visual hallucinations. The cimetidine administration was discontinued, and the patient's mental status returned to normal. During his second admission, he was not treated


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.