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Treatment of Staphylococcal Infections

Muni Barash, MD
Arch Intern Med. 1980;140(9):1249. doi:10.1001/archinte.1980.00330200125038.
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To the Editor.  —In the article "Serious Staphylococcal Infections With Strains Tolerant to Bactericidal Antibiotics" in the September Archives (139:1026-1031, 1979), the authors say that "there was no difference in the number of septicemias or cases of endocarditis between group 1 and group 2." There were differences, however, to the extent that one cannot reasonably compare clinical responses.If one counts, there were nine patients with endocarditis in group 1 and seven in group 2. In addition, one of the seven cases was that of a young drug user, known to belong to a more benign subset,1 and another of the seven (case 19) is not convincing as endocarditis. Data accumulating since the contribution of Nolan and Beaty2 have confirmed that patients with staphylococcal endocarditis will do worse (more relapses, increased risk of lethal secondary events, and requiring more prolonged antibiotic therapy) than those with staphylococcal septicemia from


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