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Proliferative Glomerulonephritis With Crescent Formation in Behcet's Syndrome

Phillip J. Olsson, MD; Eoin Gaffney, MB, BCh; Ronald W. Alexander, MD; Donald R. Mars, MD; Thomas J. Fuller, MD
Arch Intern Med. 1980;140(5):713-714. doi:10.1001/archinte.1980.00330170129039.
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• Behçet's syndrome is a multisystem disease complex, the major manifestations of which are oral and genital ulcers, arthritis, uveitis, and skin eruptions. Less frequently, CNS disturbances, colitis, thrombophlebitis, large-vessel vasculitis, and myocarditis occur. If renal involvement does occur, it is usually manifested by asymptomatic microhematuria and/or proteinuria. Recently, renal amyloidosis and focal necrotizing glomerulonephritis with immune complex deposition have been described. We describe a patient with Behçet's syndrome who experienced diffuse proliferative glomerulonephritis with epithelial cell crescent formation in 75% of glomeruli examined. Immune complexes were not identified. Renal function, impaired on admission, improved with no therapy.

(Arch Intern Med 140:713-714, 1980)


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