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Article |

Clinical Relationships Between Serum Phosphorus and Other Blood Chemistry Values in Alcoholics

Ralph S. Ryback, MD; Michael J. Eckardt, PhD; Charles P. Pautler, MA
Arch Intern Med. 1980;140(5):673-677. doi:10.1001/archinte.1980.00330170089029.
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• Hypophosphatemia was found in 11 of 434 (2.5%) male patients admitted to an alcohol treatment program and 21 of 69 (30.4%) male alcoholic patients admitted to the medical wards. In contrast, hyperphosphatemia was found in 43 of 434 (9.9%) treatment program alcoholics, and only one of 69 (1.4%) medical-ward alcoholics. Analysis of a sample of 57 nonalcoholic inpatients from the same hospital revealed one (1.8%) patient with hypophosphatemia and one (1.8%) patient with hyperphosphatemia. No relationship was found between phosphorus levels and magnesium, creatinine phosphokinase, RBCs, or hematocrit. A transient but significant (P <.05) hypophosphatemia was found between the second and fifth days after admission in a subsample of 26 medical-ward alcoholics who had had a normal serum phosphate level on admission. It is suggested that phosphate levels of less than 1.1 mg/dL may predict impending hemolysis or rhabdomyolysis in the alcoholic.

(Arch Intern Med 140:673-677, 1980)


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