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Sea-Blue Histiocytosis: A New Cause of Malabsorption Syndrome?

José L. Alvarez-Sala Jr, MD; M. Angeles Urban, MD; Juán J. Sicilia, MD; Domingo Espinos, MD, FRCP
Arch Intern Med. 1980;140(4):584. doi:10.1001/archinte.1980.00330160144059.
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To the Editor.  —Since the first description of Silverstein et al1 in 1970 of the syndrome of the sea-blue histiocyte, over 70 cases of the primary and often familial disease have been published in world literature. All of them characteristically affect diverse organs of the reticuloendothelial system, principally liver, spleen, and bone marrow, and deal with more or less common symptoms.2 Other than in the hereditary syndrome, sea-blue histiocytes have been identified in bone marrow or spleen of patients with an impressive variety of hematologic and metabolic abnormalities.3 In 1972, Silverstein and Ellefson4 had proposed criteria for the diagnosis of the primary form of the sea-blue histiocytosis. We have recently been able to study a new case of the hereditary syndrome in which, for the first time, the involvement of the intestinal mucosa has been verified, having observed a pronounced infiltration by sea-blue histiocytes in its


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