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Potentiation of Warfarin Anticoagulation by Sulfisoxazole

Leo J. Sioris, PharmD; Robert T. Weibert, PharmD; Paul R. Pentel, MD
Arch Intern Med. 1980;140(4):546-547. doi:10.1001/archinte.1980.00330160106038.
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• The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.

(Arch Intern Med 140:546-547, 1980)

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