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Metastatic Thyroid Carcinoma in Myxedema

Susan S. Braithwaite, MD; Emilio Orfei, MD; John M. Moran, MD; Edward Paloyan, MD
Arch Intern Med. 1980;140(2):282. doi:10.1001/archinte.1980.00330140140043.
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To The Editor.  —We report a case of metastatic thyroid carcinoma in primary myxedema. Autoimmunity and thyroidal atrophy may account for the rarity of this concurrence. The case also illustrates the well-known difficulty of identifying an occult thyroid carcinoma by morphologic criteria.

Report of a Case.  —A 31-year old diabetic man was admitted on July 27, 1974, for evaluation of a 2.5-cm coin lesion of the lower portion of the left lung that had been absent on a microfilm in 1972. At the age of 17 years, because of a fungal infection of the anterior aspect of the chest, he had received four weekly radiation treatments in the office of a dermatologist. The patient's mother and aunt were said to be hypothyroid.The size of the thyroid gland was estimated at 20 g. Although its surface was irregular, no discrete nodules were present. A clinical suspicion of myxedema was


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