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Hyperparathyroidism Following Head and Neck Irradiation

Sudhaker D. Rao, MB, BS; Boy Frame, MD; Martin J. Miller, MD; Michael Kleerekoper, MD; Melvin A. Block, MD; A. Michael Parfitt, MD
Arch Intern Med. 1980;140(2):205-207. doi:10.1001/archinte.1980.00330140063019.
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• A history of head and neck irradiation in childhood or adolescence was found in 22 of 130 patients with primary hyperparathyroidism compared with only 12 of 400 control patients, a significant difference (P <.025). Among 200 patients with a known history of childhood irradiation, biochemical or surgical evidence of hyperparathyroidism was found in ten, a prevalence of 5%. This is at least 30 times the prevalence of hyperparathyroidism in the general population (P <.025). The data indicate that head and neck irradiation should be regarded as an important risk factor in the subsequent development of hyperparathyroidism.

(Arch Intern Med 140:205-207, 1980)

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