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Myocardial Perfusion Scintigraphy

Elias H. Botvinick, MD
Arch Intern Med. 1980;140(2):169-171. doi:10.1001/archinte.1980.00330140027012.
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Recent progress in diagnostic cardiology has centered around noninvasive methods1,2; among these, echocardiography and myocardial scintigraphy have developed most rapidly.3-6 Probably most prominent among the diverse scintigraphic methods is relative myocardial perfusion imaging.1 The method employs an intracellular cation, most commonly thallium (TL) 201, administered in the form of thallous chloride. The TL 201 is rapidly extracted from the blood following a peripheral intravenous injection7 and is avidly taken up by the viable myocardium in proportion to relative coronary perfusion." Owing to the rapid extraction of these radionuclides and the transient stability of their localization, injection made during bicycle or treadmill exercise and imaging performed within a brief period following injection permit evaluation of myocardial perfusion present at the time of injection.9-13 Image abnormalities present on the stress study can be compared with a subsequent image performed at rest or at redistribution, three to four


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