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November 1979, Vol 139, No. 11 >

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ARTICLE | November 1979

Triiodothyronine Levels-Reply

Jacobo Wortsman, MD; Norman G. Soler, MD
Arch Intern Med. 1979;139(11):1320. doi:10.1001/archinte.1979.03630480091042.
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In Reply.—  My co-workers and I agree with Hydovitz et al regarding the uncertainty associated with the use of total T3 (radioimmunoassay) for predicting the outcome of sodium iodide I 131 therapy in hyperthyroidism. Our study was actually prompted by the suggestion that the isolated increase in the level of T3 would be an early marker of recurrence of the hyperthyroidism. Prolonged follow-ups and repetition of the determinations did not bear this out.Our report did not address the question of the mechanism for the increase in the T3 levels. Calculation of the free hormone levels would be an obvious step in that direction; better yet is the direct determination of free thyroid hormone. Nevertheless, there are also pitfalls in this determination, such as interference by free fatty acids,1 and possibly by triglycerides (I. J. Chopra, J. Wortsman, N. G. Soler, unpublished data, March 1978). Even

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