July 1979, Vol 139, No. 7 >

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ARTICLE | July 1979

Cerebellar Degeneration and Hodgkin's Disease

Nicholas Tsapatsaris, MD; Stephen L. Wanger, MD; David Steinberg, MD

Arch Intern Med. 1979;139(7):829-830. doi:10.1001/archinte.1979.03630440087033.

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To the Editor.— Paraneoplastic subacute cerebellar degeneration has only rarely been reported with Hodgkin's disease.^1-6 We report another such case.

Report of a Case.— A 48-year-old man was hospitalized in March 1976 because of progressive dysarthria, diplopia, righthanded weakness and clumsiness, and an unsteady gait since October 1975. Neurologic findings included horizontal nystagmus, slurring and dysrhythmia of speech, gross cerebellar tremor, dysmetria of all limbs, wide-based ataxic gait with inability to walk in tandem, and a positive Romberg's sign. In December 1975, WBC count in CSF was 243/cu mm, with 87% lymphocytes. Electroencephalography, isotope technetium Tc 99m brain scan, and automated computerized tomographic axial brain scan with contrast enhancement showed normal findings. The patient's symptoms worsened after treatment with corticotropin. At that time, CSF showed a WBC count of only 2/cu mm.In late May 1976, a left supraclavicular mass, measuring 5 × 5 cm, had developed; a biopsy

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Tsapatsaris N, Wanger SL, Steinberg D. Cerebellar Degeneration and Hodgkin's Disease. Arch Intern Med. 1979;139(7):829-830. doi:10.1001/archinte.1979.03630440087033.

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