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March 1979, Vol 139, No. 3 >
ARTICLE | March 1979

Antibiotic Therapy for Staphylococcal Infections

Thomas J. Halloran, MC; Michael D. Clague, MC
Arch Intern Med. 1979;139(3):376-377. doi:10.1001/archinte.1979.03630400090034.
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ABSTRACT

To the Editor.—  The recent report by Pollock et al in the June Archives (138:915-917, 1978), entitled "Hepatitis Associated With High-Dose Oxacillin Therapy," prompts us to submit the following case report.

Report of a Case.—  A 16-year-old girl sought treatment for a staphylococcal bacteremia that had developed from a skin wound of her right hand. On admission she was toxic, with a temperature of 40 °C and a WBC count of 24,000/cu mm. Her clinical response to intravenous (IV) oxacillin sodium therapy (150 mg/kg/day = 6 g/day) was gratifying; she became afebrile and asymptomatic by the third day, and remained so for the duration of her 14-day hospitalization.The SGOT level, which was normal on admission, rose to 91 mμ/mL (normal, 7 to 40) by the tenth day. The next day the value for SGOT was 140 mμ/mL and for SGPT, 109 mμ/mL (normal, 3 to 36). On day 14, the SGOT

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