We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Pathophysiology of Raynaud's Disease

Jonathan L. Halperin, MD; Jay D. Coffman, MD
Arch Intern Med. 1979;139(1):89-92. doi:10.1001/archinte.1979.03630380067022.
Text Size: A A A
Published online


Vasospasm implies reversible vasoconstriction that may diminish blood flow to supplied tissues. Initially described by Maurice Raynaud in 1862, episodic vasospastic ischemia of the digits characterizes Raynaud's phenomenon; the idiopathic variety is termed Raynaud's disease. The typical acute attack comprises sequential phases of digital pallor, cyanosis, and rubor induced by cold or emotive stimuli. The well-demarcated pallor of a part or all of one or more digits during an episode of vasospasm is presumed to derive from spastic constriction of the digital arteries or arterioles, while subsequent cyanosis is attributed to retarded blood flow in dilated capillaries and venules. After a period of minutes to several hours, local rubor develops as a consequence of reactive hyperemia. In some patients only pallor or cyanosis occurs. Dysesthesiae and regional diaphoresis may coincide with the ischemic phase, while throbbing pain often accompanies recovery. Trophic changes of sclerodactyly and, rarely, fingertip ulcerations or gangrene,


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.