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Vasopressin-Resistant Nephrogenic Diabetes Insipidus A Result of Amphotericin B Therapy

Galen L. Barbour, MD; Karl D. Straub, MD, PhD; Barry L. O'Neal, MD; James W. Leatherman, MD
Arch Intern Med. 1979;139(1):86-88. doi:10.1001/archinte.1979.03630380064021.
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Polyuria and polydipsia developed in two cases during amphotericin B therapy for deep mycoses. Neither patient could concentrate his urine in response to water deprivation or exogenous vasopressin. Other causes of vasopressin-resistant nephrogenic diabetes insipidus were not present. Three months after amphotericin B therapy had been discontinued, concentrating ability improved toward normal. A third patient was further observed and demonstrated normal diluting capacity but impaired free-water reabsorption, suggesting a distal tubular defect consistent with nephrogenic diabetes insipidus. Four months after discontinuing therapy, renal concentrating ability was normal. Amphotericin B can induce a reversible form of nephrogenic diabetes insipidus.

(Arch Intern Med 139:86-88, 1979)


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