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Article |

Rubella Antibodies and Adverse Events Late After Renal Transplantation

James P. Luby, MD; Athol J. Ware, MD; Pedro Vergne-Marini, MD; Peter Stastny, MD; Alan R. Hull, MD
Arch Intern Med. 1979;139(1):33-35. doi:10.1001/archinte.1979.03630380021010.
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Rubella antibody titers were determined pretransplant and then serially posttransplantation in 52 consecutive patients whose renal allografts survived at least three months. Group A patients (18) had antibody titers [unk] 1:128 in the posttransplant period. Group B (24) had intermediate antibody titers that never rose higher than 1:64. Group C (10) consistently had antibody titers < 1:8. Group A did not differ from groups B and C with respect to age, race, sex, type of transplant, underlying renal disease, or maximum complement fixation antibody titers posttransplant to cytomegalovirus or herpes simplex virus, type 1. Group A did differ from groups B and C in its frequency of hepatitis, chronic liver disease, episodes of late rejection ([unk] 21 days after transplant), transplant nephrectomy required for rejection, infections whose defense involves intact cell-mediated immunity, and the number of late rejection episodes per patient. Mechanisms underlying these associations are not known but apparently are not related to HLA phenotype.

(Arch Intern Med 139:33-35, 1979)


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