Corticosteroid-Induced Osteopenia

Theodore J. Hahn, MD
Arch Intern Med. 1978;138(Suppl_5):882-885. doi:10.1001/archinte.1978.03630300050010.
Text Size: A A A
Published online

Since the original description of Cushing's syndrome, it has been recognized that the prolonged maintenance of supraphysiologic levels of corticosteroids can produce severe bone loss.1,2 Studies of patients with Cushing's syndrome have demonstrated that the great majority (80% to 90%) have greatly decreased bone mass, as determined by radiological and histological criteria.2,3 Moreover, loss of bone mass occurs in a characteristic distribution; more severe osteopenia occurs in skeletal regions, such as the ribs and vertebrae, that have a high content of trabecular bone and less severe changes occur in areas such as the long bones, which are comprised primarily of compact cortical bone.1-3 As a consequence, vertebral compression and rib fractures occur commonly in this disorder.

EFFECTS OF CORTICOSTEROIDS ON BONE  Based on these observations, it is not surprising that prolonged therapeutic administration of supraphysiologic doses of corticosteroids or corticotropin often produces clinically substantial bone loss. Many


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.