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Familial Systemic Lupus Erythematosus

Kevin J. Buckman, MD; Sheila K. Moore; Allan J. Ebbin, MD, MPH; Mavis B. Cox; Edmund L. Dubois, MD
Arch Intern Med. 1978;138(11):1674-1676. doi:10.1001/archinte.1978.03630360056023.
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Pedigrees were obtained from 340 patients with systemic lupus erythematosus (SLE). Two hundred ten (62%) of the patients were from the wards or Lupus Clinic at the Los Angeles County—University of Southern California Medical Center, and 130 (38%) were from a private practice. Forty-one (12%) of the 340 patients with SLE had affected relatives: five had two and 36 had one affected relative. Ten (30%) of the 33 male patients and 31 (10%) of the 307 female patients had relatives with SLE. Examination of the individual pedigrees included examples of possible autosomal dominant, autosomal recessive, and sex-linked dominant and recessive inheritance. When all the pedigrees were considered as a group, multifactorial inheritance was suggested.

(Arch Intern Med 138:1674-1676, 1978)


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