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Generalized Lipodystrophy, Scleroderma, and Hodgkin's Disease

Steven W. Hall, MD; John J. Gillespie, MD; Theodore F. Tenczynski, MD
Arch Intern Med. 1978;138(8):1303-1304. doi:10.1001/archinte.1978.03630330097036.
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To the Editor.—  Recent reports of Sjögren's (sicca) syndrome associated with total and partial lipodystrophy1,2 prompted us to report the case of a patient with total lipodystrophy and scleroderma who has developed Hodgkin's disease.

Report of a Case.—  A 22-year-old black female was noted at 3 months of age to lack subcutaneous fat. One month later subcutaneous nodules developed on the extremities. At age 8, chronic skin changes were seen, and results of multiple skin biopsies were consistent with scleroderma (Fig 1 and 2).Recently, palpable left supraclavicular and left inguinal lymph nodes were found. Hilar and mediastinal adenopathy were seen on chest x-ray film. Esophageal abnormalities that were compatible with scleroderma were seen on barium swallow film, and old healed bone infarcts with periarticular calcifications were identified in the left ulna. Results of routine blood chemistry studies were normal. Total serum protein levels were elevated, and electrophoresis demonstrated


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