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Discordant Chronic Myelocytic Leukemia in Identical Twins

Kong-oo Goh, MD; Arthur W. Bauman, MD
Arch Intern Med. 1978;138(8):1303. doi:10.1001/archinte.1978.03630330097035.
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To the Editor.—  The Philadelphia (Ph1) chromosome, which is associated with chronic myelocytic leukemia (CML) and was first described by Nowell and Hungerford,1 has been thought to be a result of a deletion in one of the G (21 or 22) chromosomes. In the past it was not possible to determine whether the deleted parts were translocated to other chromosomes or simply lost.2 The addition of such a small segment to a large chromosome would be impossible to detect with the available techniques at that time. More precise identification of human chromosomes are now possible with the newer techniques. It appears that Ph1 chromosome is a result of a deletion of a normal chromosome 22,3 and the deleted part is translocated to another chromosome; mostly to the long arms of a chromosome 9.4We were unable to demonstrate the Ph1 chromosome in two normal


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