We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Journalistic Differentiation of Hypothesis and Conclusion in Reports of Therapy

Thomas A. Preston, MD
Arch Intern Med. 1978;138(5):687-688. doi:10.1001/archinte.1978.03630290007004.
Text Size: A A A
Published online


Without question, there is or should be a place in current medical literature for provocative clinical observations. Without reports of new observations and ideas, medical journals would be reduced to repositories for case reports and medical statistics. The question is not whether to report new observations and ideas, but how to do so without premature assumption of false conclusions with regard to those observations.

I do not object whatsoever to reports of observations or ideas and, in fact, agree that medical journals have an obligation to encourage such reports. What I believe is improper is the reporting of results and conclusions that have important clinical implications, but that are based on improper and scientifically invalid methodology. It is the relative absence of scientific thought in medicine that leads to confusion between an idea (hypothesis) and validation of the clinical application of that hypothesis.1 The problem resides in appropriate validation


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.