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Article |

A Rapid Method for the Diagnosis of Acute Uric Acid Nephropathy

John Kelton, MD; William N. Kelley, MD; Edward W. Holmes, MD
Arch Intern Med. 1978;138(4):612-615. doi:10.1001/archinte.1978.03630280074023.
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Acute uric acid nephropathy is a reversible type of renal failure that results from the deposition of uric acid crystals in the collecting tubules. The present study has compared a number of laboratory tests in 5 patients with a clinical diagnosis of this disorder and 27 patients with acute renal failure of other causes. Neither the serum creatinine, BUN, serum urate concentrations, nor the ratio of serum urate:BUN differentiated between these two groups of patients. However, the ratio of uric acid to creatinine concentration on a random urine specimen did differentiate between these two patient populations. All patients with uric acid nephropathy had a ratio greater than 1.0, while all patients with other types of acute renal failure had ratios of less than 1.0.

(Arch Intern Med 138:612-615, 1978)


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