The Multiple Factors Affecting Plasma Renin Activity in Essential Hypertension

Robert H. McDonald Jr, MD; Clinton N. Corder, PhD, MD; Anthony H. Vagnucci, MD; Joseph Shuman, MD
Arch Intern Med. 1978;138(4):557-561. doi:10.1001/archinte.1978.03630280035015.
Text Size: A A A
Published online

Seventy-nine patients with essential hypertension were evaluated for peripheral renin activity in response to injection of 60 mg of furosemide and to upright posture. Age and supine diastolic blood pressure were found to be significant determinants of responsiveness, with contributions from sex and race. Patients with impaired responsiveness were predominantly older and female, while the group of hyperresponders was younger, male, and had significantly lower supine diastolic pressures. Aldosterone responses in relation to changes in peripheral renin activity were found to be nearly random with both furosemide and with posture. Thus, patients could be subdivided into renin subgroups, but not into parallel aldosterone subgroups. Data on four patients with primary hyperaldosteronism were discussed for comparisons.

(Arch Intern Med 138:557-561, 1978)


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.