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Article |

The Principles and Practice of Diagnostic Enzymology

Larry H. Bernstein, MD
Arch Intern Med. 1977;137(12):1736-1737. doi:10.1001/archinte.1977.03630240068023.
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This text is a revision of a text, Introduction to Diagnostic Enzymology, which the author first published in 1962 to review the diagnostic applications of enzyme determinations. There has been, of course, a very rapid expansion of the use of diagnostic enzyme tests since the introduction of the serum transaminases in the mid 1950s and, subsequently, the development of isoenzyme methodologies in the mid 1960s, which the author illustrates in the first chapter. Unfortunately, there has been a considerable amount of research and development since 1973 that is beginning to have an important effect on the performance of the clinical laboratory with respect to isoenzyme methodologies, and with respect to the centrifugal analyzers. The author alludes to these developments when possible, but the fact that there are few references after 1972 might also be related to a desire on the part of the author to be conservative in the handling


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