We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Propranolol Hydrochloride for Thyrotoxicosis

G. Lotti, MD; G. Delitala, MD; L. Devilla, MD; S. Alagna, MD; A. Masala, MD
Arch Intern Med. 1977;137(10):1485. doi:10.1001/archinte.1977.03630220109030.
Text Size: A A A
Published online


To the Editor.—  The use of propranolol hydrochloride as the only drug for treating thyrotoxicosis was discussed in a recent article by Mazzaferri et al (Archives 136:50-56, 1976) and in a subsequent letter by Biran (Archives 136:1197, 1976). Mazzaferri indicated that propranolol, although not as a first choice drug, could be given with benefit at least in some cases, whereas Biran has seriously questioned its use on the grounds of the "known lack of specific effects of propranolol on the metabolism of thyroid gland...." This is not unquestionably true, since in vitro experiments have demonstrated that adrenergic mechanisms are involved in human1 and animal2 thyroid hormone secretions and are influenced by propranolol. However, the beneficial effects of propranolol in thyrotoxicosis may result from its effect on the peripheral metabolism of thyroid hormones. In fact, we demonstrated by radioimmunoassay measurements that therapeutic doses of propranolol hydrochloride (120 mg/ day)


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.