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Primary Care Medicine

Arch Intern Med. 1977;137(10):1347-1351. doi:10.1001/archinte.1977.03630220001001.
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Bracing for influenza  The 1977-1978 bivalent influenza vaccine contains inactivated influenza type A virus comparable to prototype A/Victoria/3/75 (H3N2) and inactivated type B (Hong Kong/5/72) virus.These are "representative of currently prevalent strains," says the Food and Drug Administration's Bureau of Biologics, Bethesda, Md.The vaccine is being offered in split virus (containing antigens produced by chemically disrupting the influenza virus) and whole virus preparations. The US Public Health Service's advisory committee on immunization practices says split virus vaccines "have been associated with somewhat fewer side effects than whole virus vaccines, particularly in children. However, the split virus vaccines appear to be somewhat less effective in eliciting antibodies when given as a single dose to persons who have not been 'primed' by exposure to related viruses in nature or through vaccination."The committee predicts that most adults and older children will have a strong antibody response to a single dose


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