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Hypertension and Hyperparathyroidism

Donald A. Scholz, MD
Arch Intern Med. 1977;137(9):1123-1124. doi:10.1001/archinte.1977.03630210009005.
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The detection, appropriate medical evaluation, and effective management of hypertension are important because hypertension, inadequately treated, can substantially increase the death rate not only from hypertensive heart disease but also from coronary heart disease, cerebrovascular disease, and renal insufficiency. Hypertension occurs in 22% to 50% of patients with primary hyperparathyroidism.1,2 Rosenthal and Roy3 found seven patients with primary hyperparathyroidism by the routine determination of serum calcium levels in 900 patients who were referred for investigative workup of their hypertension. Potentially reversible hypertension may occur, however, in other diseases associated with hypercalcemia.4

The basis for hypertension in primary hyperparathyroidism remains to be clarified. In 1958, Hellström et al2 concluded that most hypertension was secondary to renal damage. Recent studies,3 however, showed that the hypertension often does not correlate closely with any notable impairment in renal function. An increase in peripheral resistance seems to be an important


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