Hemolysis After Factor VIII Administration

Julia B. Ashenhurst, MD; Patricia L. Langehenning, MD; Ruth Andrea Seeler, MD
Arch Intern Med. 1977;137(8):1088. doi:10.1001/archinte.1977.03630200090025.
Text Size: A A A
Published online

To the Editor.—  Orringer and coworkers reported two cases of hemolysis, including a blood-group B individual during treatment with large doses of factor VIII concentrate (Arch Intern Med 136:1018-1020, 1976). Such hemolysis is to be anticipated in any blood-group A, B, or AB patient receiving massive doses of factor VIII preparation, whether for a surgical problem or in an attempt to overcome an inhibitor. Clinically significant hemolysis has been reported with all factor VIII preparations, including fresh frozen plasma, lyophilized plasma, fibrinogen-rich antihemophilic factor, non-type specific cryoprecipitate, and commercial concentrates. Our report of a blood-group B child without an inhibitor who developed hemolysis for seven days during the postoperative period was in press when Orringer et al were writing their paper.1Their patient 2 developed hemolysis after receiving 270,000 units of factor VIII concentrate during a four-day period, which had a saline and immune titer of 1:16. This amount


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.