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Side Effects After Treatment With Nitrofurantoin

Jacob Dimant, MD; Alexander W. Washington, MD; Aaron A. Alter, MD; David Grob, MD
Arch Intern Med. 1977;137(6):811-812. doi:10.1001/archinte.1977.03630180083024.
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To the Editor.—  Nitrofurantoin (Furadantin, Macrodantin) is a nitrofuran derivative, used mainly for urinary tract infections. A relatively high incidence of side effects, mainly gastrointestinal and dermatologic, has occurred after use of this drug. Untoward hematologic reactions have included hemolytic anemia in patients with1 or without2 glucose-6-phosphate dehydrogenase deficiency, megaloblastic anemia similar to that caused by hydantoin derivatives,3 and granulocytopenia.4-6 Aplastic anemia has not been previously described as a consequence of nitrofurantoin administration. We recently had a patient who developed fatal aplastic anemia after furadantin administration.

Report of a Case.—  A 47-year-old man was admitted because of fever and shortness of breath. Two weeks prior to admission, he had a urinary tract infection for which nitrofurantoin was prescribed. The amount of nitrofurantoin received at that time was not known. He had received nitrofurantoin on at least two previous occasions, approximately one year earlier. Two days prior to


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