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Studies With an Artificial Endocrine Pancreas

A. Michael Albisser, MASc, PhD; Bernard S. Leibel, MSc, MD; Bernard Zinman, MD; Frederick T. Murray, MD; Walter Zingg, MSc, MD; Charles K. Botz, MASc, PhD; Araceli Denoga, MD; Errol B. Marliss, MD
Arch Intern Med. 1977;137(5):639-649. doi:10.1001/archinte.1977.03630170055015.
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Short-term studies with an artificial endocrine pancreas have provided insights into the pathophysiology of diabetes and demonstrated the ability of such a system to restore and maintain glucose homeostasis in human subjects given either their usual diet, a 50 gm oral glucose tolerance test, or a moderate level of physical exercise. Animals were used to demonstrate that a peripheral route of insulin delivery by the artificial pancreas is equivalent to the portal route.

(Arch Intern Med 137:639-649, 1977)


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