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Article |

RBC Transfusions in Paroxysmal Nocturnal Hemoglobinuria

Jon P. Gockerman, MD; Robert P. Brouillard, MD, FACP
Arch Intern Med. 1977;137(4):536-538. doi:10.1001/archinte.1977.03630160092019.
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Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCs, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH.

(Arch Intern Med 137:536-538, 1977)


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