A patient with busulfan-induced pancytopenia and recurrent, thrombocytopenic bleeding was treated prophylactically with random-donor platelet transfusions and later with HLA-matched platelets from a sibling. The pancytopenia remitted after five months. The course and alternative modes of therapy of busulfaninduced pancytopenia are discussed. This disorder may be reversible if the patient can be supported through an initial period of severe pancytopenia.
(Arch Intern Med 136:1181-1183, 1976)