The Clinical Features of Sickle Cell Disease

Howard A. Pearson, MD
Arch Intern Med. 1976;136(5):625. doi:10.1001/archinte.1976.03630050099018.
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For the past decade, Graham Serjeant, a young British hematologist, has traveled the mountain roads of Jamaica in a Volkswagen microbus to scattered rural clinics, accumulating a vast amount of information about the clinical symptoms, epidemiologic features, and prognosis of sickle cell anemia. The book represents a review of sickle cell disease against the background of this experience.

The first seven chapters are general reviews. The molecular biochemistry, the physiochemical basis of sickling, tests for sickle hemoglobin, demography, genetics, and history of sickle cell disease are concisely, but authoriatively, presented. Thereafter, sickle cell disease is dissected organ by organ and body system by body system. In each chapter, the author has done a competent job of summarizing the enormous literature on sickle cell disease, citing nearly 1,500 articles.

A criticism of the presentation of sickle cell disease in this book is the author's therapeutic nihilism. This is doubtless conditioned by


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