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Hot Flashes and Sweats in Men With Testicular Insufficiency

Jerome M. Feldman, MD; R. W. Postlethwaite, MD; James F. Glenn, MD
Arch Intern Med. 1976;136(5):606-608. doi:10.1001/archinte.1976.03630050082013.
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Cessation of ovarian function in women frequently results in the climacteric or menopausal syndrome. Vasomotor symptoms, such as hot flashes and sweating attacks, are the most prominent complaints and are reported by 62% of women undergoing the menopause.1 In contrast, reduction in testicular function in men usually occurs gradually, if at all, and usually does not result in specific manifestations.2 (pp493-494) Occasionally, however, as a result of testicular failure, men develop a syndrome known as the male climacteric. The chief symptoms of the male climacteric are loss of libido and sexual potency, irritability, depression, and inability to concentrate. Vasomotor symptoms such as hot flashes and sweating, typical of the menopausal syndrome in women, are less common in the male climacteric.

Recently we have studied three men who developed hot flashes and sweating after loss of testicular function. These vasomotor symptoms were completely reversed by adequate androgen replacement. Previous


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