Mucosal Response to Esophageal Motor Disorders

Charles E. Pope II, MD
Arch Intern Med. 1976;136(5):549-555. doi:10.1001/archinte.1976.03630050037008.
Text Size: A A A
Published online

The mucosa of the esophagus is involved in only one disorder of motor function, lower esophageal sphincter (LES) incompetence. Although long-standing megaesophagus in untreated achalasia used to be associated with inflammation, leukoplakia, and carcinomatous degeneration,1,2 modern treatment has made such mucosal changes distinctly more uncommon. This communication, therefore, discusses changes in the esophageal mucosa brought about by reflux of gastrointestinal contents into the esophagus through an incompetent LES.

METHODS OF MUCOSAL EVALUATION  Several different methods of studying the esophageal mucosa are available, both clinically and experimentally. Roentgenographic contrast study of the mucosa during a barium swallow certainly is the most common form of investigation employed clinically, but unfortunately it is one of the least sensitive. Unless mucosal damage has progressed to deep ulceration or stricture formation, the barium examination of the esophageal mucosa will usually be reported as normal.3 This is not surprising, since primary mucosal diseases in


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.