Sudden Death Caused by Benign Tumor of the Atrioventricular Node

Saroja Bharati, MD; J. Pedro Bicoff, MD; Jaime L. Fridman, MD; Maurice Lev, MD; Kenneth M. Rosen, MD
Arch Intern Med. 1976;136(2):224-228. doi:10.1001/archinte.1976.03630020078017.
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Mesothelioma of the atrioventricular (AV) node, although a benign tumor, is a known cause of sudden cardiac death.1 This association is surprising, in that the tumor location should produce a site of block proximal to the His bundle, which is ordinarily consistent with a favorable clinical course.2-6

The present report concerns a 16-year-old girl with acquired heart block, sudden death, and pathological studies demonstrating a mesothelioma of the AV node. The case is unique in that His-bundle recordings were obtained that verified a localized site of AV block consistent with the location of the tumor. This case is of particular interest, since previous correlative studies of His-bundle recording and serial section of the conduction system have been attempted generally in patients with multiple electrophysiologic and pathologic sites of conduction disease,7-12 rather than with a localized site as in our patient.

PATIENT SUMMARY  The patient was a gravida


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