We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Meningoencephalitis Caused by Histoplasma capsulatum:  Occurrence in a Renal Transplant Recipient and a Review of the Literature

Rajah Karalakulasingam, MD; Krishan K. Arora, MD; Garret Adams, MD; Frank Serratoni, MD; Denis G. Martin, MD
Arch Intern Med. 1976;136(2):217-220. doi:10.1001/archinte.1976.03630020071015.
Text Size: A A A
Published online

Invasion of the central nervous system by Histoplasma capsulatum is a rare occurrence; there have been only 32 cases of this complication reported in the English literature up to 1964, and all of these cases were in non-immunosuppressed patients. With the increase in the number of renal transplants over the past ten years in this country, it might be reasonable to expect to see a greater incidence of this complication in immunosuppressed patients. Histoplasmosis is highly endemic in the states of Indiana, Ohio, Illinois, Kentucky, Missouri, Tennessee, Kansas, and Mississippi. By February 1974, 2,101 renal transplants had been done in these states (figure obtained from the transplant registry, American College of Surgeons), and there were no reports of this complication occurring in any of these patients. In this report we describe the clinical and pathological features of a case of meningoencephalitis caused by Histoplasma capsulatum in a renal transplant patient.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.