This book is the result of a Biennial International Symposium presented by the Department of Ophthalmology in Iowa City. The contributors represent a distinguished group of ophthalmologists, internists, and dermatologists. The text encompasses a broad variety of topics, including metabolic, collagen, and rheumatic, endocrine, vascular, hematologic, and skin disease, and specifically excludes infectious and neurological disorders. Each of the chapters is extremely well written and is followed by a panel discussion. Internists will find a wealth of material in this publication that will help evaluate eye findings in systemic disease.