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Individual Therapy for Patients With Hyperthyroidism-Reply

Penn G. Skillern, MD
Arch Intern Med. 1975;135(10):1405. doi:10.1001/archinte.1975.00330100131022.
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Dr Goldman implies in his letter that we did not individualize the therapy for our patients. Our paper clearly indicates that the therapy was individualized, however imprecise this may be, but that large dosages of sodium iodide I 131 were used. His letter indicates that he used individualized small to moderate doses of sodium iodide I 131 and that this resulted in a decrease in the incidence of hypothyroidism, with a total of 11% by the first five years. Glennon and associates,1 using a small dosage of sodium iodide I 131 in the treatment of Graves disease with hyperthyroidism, reported an incidence of 7.5% of hypothyroidism five years after therapy and noted that the incidence increased 3.4% each subsequent year to the 17th year, so that by the 17th year, they had a 48% incidence of hypothyroidism. Dunn and Chapman2 using moderate dosages of 160 microcuries of


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