To the Editor.
—I disagree with the method of treatment of hyperthyroidism described in the recent article in the Archives by Ali M. Safa, MD, and Penn G. Skillern, MD (135:673-675, 1975). Instead of this large initial dose, I individualize the therapy for each patient. In the first 100 patients treated at Queens Hospital Center, Jamaica, NY, the immediate incidence of hypothyroidism was 5% and 11% the first five years for the same 100 patients.In 70% of our cases, one dosage was sufficient to bring the patient to a euthyroid state. In another 25%, a second dosage was given, rarely was a third necessary. Our usual dosage ranged from 2 to 15 millicuries of sodium iodide I 131. In the treatment schedule, the most important factor was whether or not the thyroid gland was nodular. As a rule, I found that a dosage of 2.5 millicuries of sodium iodide