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Article |

Hemolytic Anemia With IgG and IgM Autoantibodies and Alloantibodies

John H. Crookston, MD
Arch Intern Med. 1975;135(10):1314-1315. doi:10.1001/archinte.1975.00330100040006.
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In discussing Dr. Dacie's Whipple Lecture, it is difficult for me to add anything to his lucid and stimulating presentation. Instead, I thought it appropriate, in tribute to both Lawrence Young and John Dacie, to try to show how their experience, at the bench and at the bedside, can be applied to the investigation and management of the individual patient with autoimmune hemolytic anemia (AIHA). To do this, I shall present the history and serological findings of a patient whose case illustrates some of the serological complexities that may be encountered in patients with AIHA, and some of the problems of management which they pose.

PATIENT SUMMARY  A 70-year-old man was referred to Toronto in August 1974 because it had become impossible to find compatible blood for transfusion.There is little information about the early months of his illness. He became severely anemic suddenly, in January 1974. There was no


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