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Noradrenaline-Secreting Glomus Jugulare Tumor With Cyclic Change of Blood Pressure

Hideyo Matsuguchi, MD; Masazumi Tsuneyoshi, MD; Akira Takeshita, MD; Motoomi Nakamura, MD; Toshihiko Kato, MD; Kikuo Arakawa, MD
Arch Intern Med. 1975;135(8):1110-1113. doi:10.1001/archinte.1975.00330080112018.
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Since Rosenwasser1 reported the tumor of glomus jugulare in 1945, a number of cases have been reported; however, only a few cases showed evidence of catecholamine secretion.2-5 Glomus jugulare tumor has been considered to originate embryologically in the neural crest and has been classified as a nonchromaffin paraganglioma because of the lack of chromaffinity. Previously only pheochromocytoma, among various neurogenic tumors, had been considered to secrete catecholamine, but since Mason et al6 in 1957 reported a case of adrenaline-secreting neuroblastoma, a close relationship of neurogenic tumors to abnormal catecholamine secretion7 has been recognized.

We report a noradrenaline-secreting tumor of the glomus jugulare with catecholamine granules shown electron microscopically. Continuous recording of blood pressure showed a peculiar cyclic change of the pressure.

METHODS  Catecholamine was measured by a modification of the trihydroxyindole fluorimetric method of von Euler and Floding.8 Levels of urinary total metanephrine (TMN)


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