0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency

Eulalia Harbaugh, MT; Thomas Kickler, MD
Arch Intern Med. 1975;135(3):490. doi:10.1001/archinte.1975.00330030140017.
Text Size: A A A
Published online

To the Editor.  —In the article entitled "Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency" in the August issue, Esham et al describe a patient with a case of severe hemorrhagic disorder. An important consideration, which the authors apparently failed to recognize, is that this patient may also have a circulating anticoagulant. This is suggested by the severity of the patient's bleeding tendency despite a factor VIII value of 28% and the development of an abnormal partial thromboplastin time after a bleeding episode that may represent an amnestic increase in the circulating anticoagulant level after therapeutic administration of factor VIII. The lack of response to plasma components containing factor VIII also suggest the presence of an inhibitor to factor VIII.Despite the authors' claim of presenting the first case of hereditary telangiectasia and factor VIII deficiency, Quick has previously described the cases of two patients with these defects.1 In these patients,

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();