We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Toward a Hopeful Outlook in Acute Granulocytic Leukemia

John N. Bickers, MD; Edmund A. Genhan, PhD; Charles A. Coltman Jr., MC; Henry E. Wilson, MD; James S. Hewlett, MD; W. J. Stuckey, MD; Ellis J. Van Slyck, MD
Arch Intern Med. 1975;135(3):489-490. doi:10.1001/archinte.1975.00330030139015.
Text Size: A A A
Published online


To the Editor.  —A recent editorial1 entitled "Grounds for Optimism in Treating Acute Granulocytic Leukemia" again characterizes the well-recognized pessimistic view of the past that the disease is hopeless and inevitably fatal.Let us examine the facts based on a recent update (Dec 15, 1974) of the Southwest Oncology Group report on the management of acute leukemia with cytarabine (Cytosar).2 The Table includes all the patients in the study who survived longer than 135 weeks. Eleven of the 48 patients who achieved complete remission lived longer than 135 weeks (2.6 years). Of those 11 patients, three had relapses at 151 weeks (2.9 years), 221 weeks (4.3 years), and 226 weeks (4.3 years). There have been no additional relapses with follow up to 353 weeks (6.8 years). Three of the eight remaining patients died of causes other than their acute leukemia. A 56-year-old man died of a brain metastasis


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.