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Treatment of Fungal Infections With Flucytosine

Edward J. Harder, MD; Paul E. Hermans, MD
Arch Intern Med. 1975;135(2):231-237. doi:10.1001/archinte.1975.00330020035003.
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Treatment with flucytosine of 20 patients with fungal infections gave favorable results in four patients with cryptococcal infections, two of four patients with disseminated candidiasis, eight of ten patients with urinary tract infections due to Candida albicans and Torulopsis glabrata, and two of three patients with miscellaneous infections due to C albicans. Two patients with cryptococcal meningitis and altered host resistance and one patient with an aortofemoral graft infection due to C albicans were treated with flucytosine and amphotericin B. The infection was eradicated in one of the patients with meningitis, and cultures from an infected arterial graft became negative. Adverse side effects of flucytosine included mild leukopenia and thrombocytopenia, a transient increase in alkaline phosphatase and glutamic oxaloacetic transaminase, and nausea and diarrhea.


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