Thiothixene-Induced Hyponatremia

Kamel Ajlouni, MD; Martin W. Kern, MD; John F. Tures, MD; George B. Theil, MD; Thad C. Hagen, MD
Arch Intern Med. 1974;134(6):1103-1105. doi:10.1001/archinte.1974.00320240137019.
Text Size: A A A
Published online

Since the initial description by Schwartz et al1 of a syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with bronchogenic carcinoma, a number of other disease entities2-5 have been reported in association with this phenomenon. In addition, a number of therapeutic agents have been incriminated, including vincristine,6 cyclophosphamide,7 clofibrate,8 and chlorpropamide.9 The latter agent, as well as acetaminophen,10 has been used therapeutically in diabetes insipidus. The purpose of this communication is to report an additional drug, thiothixene (Navane), as an apparent cause of SIADH.

Patient Summary  A 55-year-old man was admitted to the Medical Service of the Wood Veterans Administration Center in April of 1973 because of confusion, lethargy, and anorexia. He had been treated for undifferentiated schizophrenia for at least 20 years with phenothiazine derivatives, including chlorpromazine and trifluoperazine. Four months prior to admission he had been placed on


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.