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Immunopathology of the Renal Glomerulus: Immune Complex Deposit and Antibasement Membrane Disease

Leonard B. Berman, MD
Arch Intern Med. 1974;134(4):788. doi:10.1001/archinte.1974.00320220190039.
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I cannot believe I read the whole thing! But I did and enjoyed it. In a brief and clearly written monograph, the editors have summarized the experimental and clinical evidence on which present concepts of immune disease of the glomeruli is based. The major portion of the book is given over to a well-illustrated exposition of the two major pathways of immune diseases of the glomeruli. Circulating complex diseases receive the most attention, and the authors emphasize the importance of complex size in determining the occurrence and type of glomerular lesions. They have not hesitated to introduce newly coined terms; eg, type 1 complexes are those characterized as small, soluble, and able to pass through the basement membrane to emerge on the other side as subepithelial deposits, while type 2 complexes are larger, less soluble and tend to be trapped in the mesangial or subendothelial layer of the basement membrane.


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