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Pure Red Blood Cell Aplasia and Chronic Lymphocytic Leukemia

Martin D. Abeloff, MD; Larry Waterbury, MD
Arch Intern Med. 1974;134(4):721-724. doi:10.1001/archinte.1974.00320220123016.
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Acquired pure red blood cell (RBC) aplasia (PRCA) is a rare hematologic disorder characterized by anemia, absence of reticulocytosis, erythroid hypoplasia in the bone marrow, and no abnormalities of the myeloid and megakaryocytic lines.1,2 The anemia is severe and generally normochromic and normocytic. Approximately 50% of adults with PRCA have thymomas.3-5 It has also been associated with a variety of disorders including neoplasms,6 preleukemic states,1,7 riboflavin deficiency,8 renal failure,9 and exposure to drugs.10 Pure RBC aplasia has been reported also in adults who have no other medical disorders or history of exposure to toxins.2

Dameshek and colleagues have referred to occasional cases of chronic lymphocytic leukemia in which the anemia was associated with erythroblastopenia and reticulocytopenia.4 Tatarsky11 and Stohlman et al12 have recently described PRCA as a rare cause of anemia in chronic lymphocytic leukemia. Our report describes a


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